Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
نویسندگان
چکیده
To study the evolution of dengue virus (DENV) serotype 2 in Puerto Rico, we examined the genetic composition and diversity of 160 DENV-2 genomes obtained through 22 consecutive years of sampling. A clade replacement took place in 1994-1997 during a period of high incidence of autochthonous DENV-2 and frequent, short-lived reintroductions of foreign DENV-2. This unique clade replacement was complete just before DENV-3 emerged. By temporally and geographically defining DENV-2 lineages, we describe a refuge of this virus through 4 years of low genome diversity. Our analyses may explain the long-term endurance of DENV-2 despite great epidemiologic changes in disease incidence and serotype distribution.
منابع مشابه
Global evolutionary history and spatio-temporal dynamics of dengue virus type 2
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2011